Process for the preparation of 3-substituted 7-aminocephalospora

Details Process for the preparation of 3-substituted 7-aminocephalospora Process for the preparation of 3-substituted 7-aminocephalospora

1982-08-24

1984-11-06

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 26, 544 27, 544 21, 544 29, 2602452R, 2602453, C07D50118, A61K 31545

Patent

active

044813570

ABSTRACT:
A 3-substituted 7-aminocephalosporanic acid of formula: ##STR1## where R.sub.1 is hydrogen, methyl of methoxy, Y is nitrogen, oxygen sulphur or a sulphoxide group, R.sub.2 is a group selected from among azide or from a radical having the formula R.sub.3 --S-- where R.sub.3 may be, among others, alkyl, aliphatic acyl, methyl and chlorine or methoxy substituted aromatic acyl, is prepared. A compound of formula ##STR2## (X being chlorine, carbamoyloxy or acetoxy) is added to a medium constituted by water, a compound which may be nitric acid or a compound of formula R.sub.3 --SH and a tertiary organic base. With a reaction isoelectric pH regulator, the mixture takes on a specific process pH analytical profile, the compounds of said mixture being reacted together at particular temperatures and with a specific process time.

REFERENCES:
patent: 4312986 (1982-01-01), Saikawa et al.

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