Process for the preparation of 3-phenylpropionic acid

Details Process for the preparation of 3-phenylpropionic acid Process for the preparation of 3-phenylpropionic acid

1997-04-16

1998-07-28

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562400, 562405, 562407, 562409, C07C 51235, C07C 5116

Patent

active

057865078

ABSTRACT:
Process for the preparation of 3-phenylpropionic acid in which 3-phenylpropanal is subjected to an oxidation, at elevated temperature, in particular at a temperature of between 40.degree. and 80.degree. C., using a medium containing molecular oxygen. A high degree of conversion and a high selectivity are obtained. The starting material 3-phenylpropanal can be prepared in a suitable manner through the hydrogenation of cinnamaldehyde in the presence of a Pd-containing catalyst, after which the reaction mixture obtained can without intermediate further processing be used in the oxidation reaction. The combination of the two process steps constitutes a simple, commercially attractive process for the preparation of 3-phenylpropionic acid using cinnamaldehyde as a starting material. 3-phenylpropionic acid can be used in particular in the preparation of pharmaceuticals such as HIV protease inhibitors.

REFERENCES:
patent: 3520934 (1970-07-01), Dunkel et al.

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