Process for the preparation of 3-phenylpropanal

Details Process for the preparation of 3-phenylpropanal Process for the preparation of 3-phenylpropanal

1997-04-16

1998-09-22

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

562408, 562415, C07C 4562

Patent

active

058115889

ABSTRACT:
Process for the preparation of 3-phenylpropanal in which cinnamaldehyde is hydrogenated with the aid of a Pd-containing catalyst in the presence of a small amount of water. A high yield and a high selectivity are obtained in a commercially attractive process. The reaction mixture obtained can without intermediate further processing be subjected to an oxidation in which the cinnamaldehyde is oxidized to 3-phenylpropionic acid with a high degree of conversion and a high selectivity. The combination of the two process steps constitutes a simple, commercially attractive process for the preparation of 3-phenylpropionic acid using cinnamaldehyde as a starting material. The resulting 3-phenyl-propionic acid product may serve as an intermediate reagent in the synthesis of anti-viral pharmaceuticals, particularly HIV protease inhibitors.

REFERENCES:
patent: 3520934 (1970-07-01), Dunkel et al.

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