Process for the preparation of 3-methylcepham derivatives

Details Process for the preparation of 3-methylcepham derivatives Process for the preparation of 3-methylcepham derivatives

2007-09-25

2007-09-25

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C540S230000, C540S310000

Reexamination Certificate

active

10922992

ABSTRACT:
A process for the preparation of 3-methylcepham-4-carboxylate of the formula (I).wherein R2and R3may be same or different and represent hydrogen, halogen, amino, alkyl, phenacetamido, substituted acetamido, phthalimido with a proviso that both R2and R3are not NH2, phenacetamido, phthalimido and the like; R1represents a lower alkyl, p-methoxybenzyl, p-nitrobenzyl, o-nitrobenzyl, o-methoxybenzyl, o-chlorobenzyl or diphenylmethyl group, or a suitable ester residue which can be deprotected at a latter stage, L represents a leaving group; which comprises cyclizing the compound of formula (III)using a cyclizing agent in the presence of organic or inorganic nitrites and a solvent at a temperature in the range of −40° C. to +60° C. to obtain compound of formula (I).

REFERENCES:
patent: 4218374 (1980-08-01), Kamiya et al.
Tanaka, Bulletin of the Chemical Society of Japan 62 (1989) , No. 9 pp. 3046-3048.

Affiliated with

Also associated with

Rating

Process for the preparation of 3-methylcepham derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 3-methylcepham derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 3-methylcepham derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3803113