Process for the preparation of 3-keto, 5-hydroxy simvastatin ana

Details Process for the preparation of 3-keto, 5-hydroxy simvastatin ana Process for the preparation of 3-keto, 5-hydroxy simvastatin ana

1989-06-23

1990-10-23

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

4352535, 435886, C12P 1706, C12R 1645

Patent

active

049652001

ABSTRACT:
A biotransformation for the formation of a 3-keto-5-hydroxy simvastation analog (I) or a 8-acyloxy derivative thereof is disclosed. ##STR1##

REFERENCES:
patent: 4448979 (1984-05-01), Terahara et al.
patent: 4517373 (1985-05-01), Terahara et al.
patent: 4537859 (1985-08-01), Terahara et al.
patent: 4921974 (1990-05-01), Duggan
U.S. Pat. application Ser. No. 213,010, filed 6/29/88.
U.S. Pat. application Ser. No. 250,646, filed 9/29/88.

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