Process for the preparation of 3-isoxazolecarboxylic acid

Details Process for the preparation of 3-isoxazolecarboxylic acid Process for the preparation of 3-isoxazolecarboxylic acid

1997-07-28

1998-06-02

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D26108

Patent

active

057602441

ABSTRACT:
A process for the preparation of 3-isoxazolecarboxlic acid which is an intermediate for prepearing useful compounds is provided, said process being characterized in that a compound of formula (I) is reacted with hydroxylamine to obtain a compound of formula (II), and the compound thus obtained is treated with an alkali: ##STR1## wherein R.sup.1 is a lower alkyl, R.sup.2 is a carboxy protecting group, X is a halogen atom, and Y is a hydrogen atom, or X and Y together may form a single bond.

REFERENCES:
patent: 5374605 (1994-12-01), Hellenbach et al.
patent: 5399577 (1995-03-01), Shindo et al.
patent: 5514505 (1996-05-01), Limburg et al.
patent: 5633272 (1997-05-01), Talley et al.
"Dehydrochlorination of Hydroximic Acid Chlorides by the Use of Organotic Compounds: An Application for Synthesis of Isoxazolines and Isoxazoles", Moriya et al., J. Chem. Soc. pp. 17-18 vol. 1., 1991.
O. Mumm et al., "Uber die freie Aceton-oxaisaure und ihre Abkommlinge", Chemische Berichte, vol. 45, 1912, pp. 3042, 3045, 3046.

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