Process for the preparation of 3 iodo- and 3 bromorifamycin s

Details Process for the preparation of 3 iodo- and 3 bromorifamycin s Process for the preparation of 3 iodo- and 3 bromorifamycin s

1978-11-06

1979-12-18

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, C07D49808

Patent

active

041794389

ABSTRACT:
A process is disclosed for the preparation of 3 iodo-3 bromorifamycin S which consists in reacting rifamycin S with at least 2 equivalents of the corresponding halogen in the presence of at least one mole of pyridine for each equivalent of halogen. The reaction is carried out in inert, polar, hydrofillic solvents at a temperature not above the room temperature. The yields are very high and the products obtained have a high degree of purity.

REFERENCES:
Dampier et al. "J. Am. Chem. Soc." vol. 98, No. 22, pp. 7064-7069 (1976)

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