Process for the preparation of 3-iminomethyl derivatives of rifa

Details Process for the preparation of 3-iminomethyl derivatives of rifa Process for the preparation of 3-iminomethyl derivatives of rifa

1983-04-11

1984-05-22

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, 424251, C07D49108

Patent

active

RE0315877

ABSTRACT:
A process for the preparation in homogeneous phase and in quantitative yield of 3-iminomethyl derivatives of rifamycin SV useful as antibiotic agents. Rifamycin S is reacted in an organic solvent with a compound ##STR1## to give a solution of [1,3-oxazino-(5,6-c) rifamycins] an intermediate compound which is treated with an organic solvent at a pH from 4 to 6. The aqueous phase is discharged and the organic phase is treated with an amine or hydrazine under basic conditions, the desired derivatives being finally isolated from this organic phase according to usual techniques.

REFERENCES:
patent: 3342810 (1967-09-01), Maggi et al.
patent: 3349082 (1967-10-01), Maggi et al.
patent: 3542762 (1970-11-01), Gianantonio et al.
Tsukamoto et al., "Chem. Pharm. Bull.", (Japan), vol. 28, No. 8, pp. 2309-2317, (1980).
"Chemical Abstracts", vol. 90, 1979, Item 204,159b, abstracting, (Japan) Kokai Tokkyo Koho, 78,147,097, Dec. 21, 1978.

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