Process for the preparation of 3-hydroxy-2-methylbenzoic acid an

Details Process for the preparation of 3-hydroxy-2-methylbenzoic acid an Process for the preparation of 3-hydroxy-2-methylbenzoic acid an

1998-02-06

1999-06-08

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

568647, 260665G, C07C 6500

Patent

active

059106050

ABSTRACT:
The invention relates to a process for the preparation of 3-hydroxy-2-methylbenzoic acid and 3-acetoxy-2-methylbenzoic acid, which comprises reacting 3-chloro-2-methylphenol (3) with benzyl chloride to give 2-benzyloxy-6-chlorotoluene (4) subjecting this to a Grignard reaction with magnesium to give (3-benzyloxy-2-methylphenyl)magnesium chloride (5) reacting this with CO.sub.2 to give 3-benzyloxy-2-methylbenzoic acid (6) hydrogenating this or its alkali metal salts in the presence of a hydrogenation catalyst to give 3-hydroxy-2-methylbenzoic acid (2) and optionally acetylating this to give 3-acetoxy-2-methylbenzoic acid.

REFERENCES:
Noelting et al., Chem. Berichte, 37, 1015, (1904).

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