Process for the preparation of 3-(.DELTA..sup.4 -3-ketosteroid-1

Details Process for the preparation of 3-(.DELTA..sup.4 -3-ketosteroid-1 Process for the preparation of 3-(.DELTA..sup.4 -3-ketosteroid-1

1984-02-22

1985-03-26

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603974, C07J 2100

Patent

active

045072388

ABSTRACT:
A simple process for preparing 3-(.DELTA..sup.4 -3-keto-steroid-17.alpha.-yl)propionic acid lactones of the androstane series represented by the general partial formula ##STR1## wherein ABCD represents an optionally substituted cyclopentanophenanthrene steroid molecule skeleton, from corresponding 17.alpha.-(3-hydroxypropynyl)-17.beta.-hydroxy steroids, comprises reducing the latter to the 17.alpha.-(3-hydroxypropenyl)17.beta.-hydroxy steroid, effecting ring closure to the lactol, and subsequently oxidizing with chromic acid to the lactone.

REFERENCES:
patent: 4057543 (1977-11-01), Dryden, Jr. et al.
patent: 4058522 (1977-11-01), Ke Kesy et al.
patent: 4129564 (1978-12-01), Wiechert et al.

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