Process for the preparation of 3-amino-pentan-1,5-diol

Details Process for the preparation of 3-amino-pentan-1,5-diol Process for the preparation of 3-amino-pentan-1,5-diol

2008-06-09

2009-12-22

Zucker, Paul A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S160000

Reexamination Certificate

active

07635784

ABSTRACT:
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one (1) a MAP-kinase inhibitor useful in the treatment of rheumatoid arthritis.

REFERENCES:
patent: 2005/0107408 (2005-05-01), Goldstein
patent: 2008/0154063 (2008-06-01), Cain et al.
patent: 1 106 614 (2001-06-01), None
patent: WO 01/29401 (2001-04-01), None
patent: WO 02/18379 (2002-03-01), None
patent: WO 02/64594 (2002-08-01), None
patent: WO 2008/068171 (2008-06-01), None
patent: WO 2008/077799 (2008-07-01), None
Lesma et al,Jour. of Orgnaic Chem., 71 (2006) 3317-3320 XP002504521.
Ohno M et al,Jour. of the Amer. Chem. Soc., 103:9, (1981) 2405-2406 XP001155281.
Adachi, K et al,Chimia, Aarau, CH, 40:9 (1986) 311-314 XP002049345.
Liu, Y-S et alJour. of Organic Chem.63, 3471-3473, (1998) XP00257609.
Tomori et al,Heterocycles, 44(1) (1997) 213-225 XP001539296.
Grob et al., Helvetica Chimica Acta, vol. 8, pp. 2145-2155 (1964).
Feuer et al., J. Amer. Chem. Socl. vol. 77 pp. 5427-5428 (1955).
Aycock, D. F. Organic Process Research & Development vol. 11 pp. 156-159 (2007).
Josey et al., J. Org. Chem. vol. 27 pp. 2466-2470 (1962).

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