Process for the preparation of 3-amino-2-hydroxy-4-phenylbutyron

Details Process for the preparation of 3-amino-2-hydroxy-4-phenylbutyron Process for the preparation of 3-amino-2-hydroxy-4-phenylbutyron

1997-12-19

1998-11-10

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C25500

Patent

active

058346180

ABSTRACT:
3-Amino-2-hydroxy-4-phenylbutyronitrile derivatives represented by the formula (3) may be prepared by reacting an aminoaldehyde derivative represented by the formula (1) with a cyanohydrin derivative represented by the formula (2) in the presence of a metallic compound, base, or acid; ##STR1## wherein R.sup.1 and R.sup.2 each independently represents a hydrogen atom or a protective group for an amino group, R.sup.3 and R.sup.4 each represents an alkyl or cycloalkyl group or R.sup.3 and R.sup.4 together form a tetramethylene or pentamethylene group.

REFERENCES:
H. Suda et al, J. Antibiotics, vol. XXIX, No. 5, pp. 600-601 (1976).
M. T. Reetz et al, Tetrahedron Letters, vol. 29, No 27, pp. 3295-3298 (1988).
R. Herranz et al, Synthesis, pp. 703-706 (1989).
Tetsushi Saino, et al., The Journal of Antibiotics, vol. 40, No. 8, pp. 1165-1169, "Synthesis of .sub.p -Hydroxyubenimex", 1987.
Derwent Abstract, AN--90-063689, JP 880165910, Jul. 5, 1998.
Chemical Abstracts, vol. 123, No. 3, p. 909, Jul. 17, 1995.

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