Process for the preparation of 3-(4'-bromobiphenyl-4-yl)tetralin

Details Process for the preparation of 3-(4'-bromobiphenyl-4-yl)tetralin Process for the preparation of 3-(4'-bromobiphenyl-4-yl)tetralin

1988-05-11

1989-10-10

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

560 53, 562492, C07C 4545

Patent

active

048733636

ABSTRACT:
A new process for the preparation of a 3-(4'-bromobiphenyl-4-yl)tetralin-1-one known as a key intermediate for the production of rodenticides and clinical medicines is provided. The title compound is prepared from P-bromobiphenylbenzylketone in three steps, wherein one of key inventions is dehydroxylation of 3-(4'-bromobiphenyl)-3-hydroxy-4-phenylbutyric acid ethyl ester using trialkylsilane in trifluoroacetic acid. This new process offers a high yield with a facile way and is more suitable for a commercial production than the prior art methods.

REFERENCES:
patent: 4035505 (1977-07-01), Hadler et al.
Fieser et al, "Reagents for Organic Synthesis", vol. 6, p. 616 (1977).

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