Process for the preparation of 3(3-carboxy-propyl)-5-methoxyindo

Details Process for the preparation of 3(3-carboxy-propyl)-5-methoxyindo Process for the preparation of 3(3-carboxy-propyl)-5-methoxyindo

1994-07-15

1995-08-29

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548492, C07D20942

Patent

active

054461693

ABSTRACT:
The invention relates to a new process for the preparation of 3-(3-carboxypropyl)-5-methoxyindole-2-carboxylic acid (I), characterized in that 6-carboethoxy-6-p-methoxyphenylhydrazonohexanoic acid (II) is cyclized using a carboxylic acid which contains 1-3 carbon atoms, the resulting mixture comprising I, the two I monoethyl esters and I diethyl ester is treated with a strong inorganic base, and the resulting salt is converted into the free acid I by treatment with a strong acid.

REFERENCES:
Hausberg et al., "Indole-alkyl-piperidines, a New Class of Dopamine Agonists", Acta Pharmaceutica Suecica, Suppl. 1983:2, 20-23 Apr. 1982.
Clack et al., "Electrophilic Substitution in Indoles, etc . . . ", J. Chem. Soc., Perkin Trans. II 1982, pp. 909-916.

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