Process for the preparation of (2S)-tetrahydro-2.alpha.-methyl-6

Details Process for the preparation of (2S)-tetrahydro-2.alpha.-methyl-6 Process for the preparation of (2S)-tetrahydro-2.alpha.-methyl-6

1981-04-08

1982-11-23

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2602452T, 260239A, 548453, 560171, C07D30930

Patent

active

043606849

ABSTRACT:
Disclosed is a process for preparing (2S)-tetrahydro-2.alpha.-methyl-6-oxo-4.beta.-amino-2H-pyran-3.alpha.-carb oxylic acid (I) which is useful in the synthesis of thienamycin. The process proceeds via a stereospecific reduction of the 2-acetyl-3-(R)-.alpha.-methylbenzylamino-2-pentenedioic acid diester (II). ##STR1## wherein R is, .alpha.-methylbenzyl, and R.sup.1 is lower alkyl having 1-6 carbon atoms or arylalkyl such as benzyl.

REFERENCES:
patent: 4269772 (1981-05-01), Melillo et al.
patent: 4282148 (1981-08-01), Liu et al.
patent: 4287123 (1981-09-01), Liu et al.

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