Process for the preparation of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C548S469000, C514S412000

Reexamination Certificate

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07968732

ABSTRACT:
The present invention is related to a process for the preparation of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1H-Indole (formula-1, a useful intermediate for the synthesis of bazedoxifene) using 4-benzyloxy propiophenone and 4-benzyloxy phenyl hydrazine hydrochloride.

REFERENCES:
patent: 5998402 (1999-12-01), Miller
patent: 0082183 (1997-10-01), None
patent: 2008098527 (2008-08-01), None
Chris P. Miller, et al. Design, Synthesis, and Preclinical Characterization of Novel, Highly Selective Indole Estrogens, Journal of Medicinal Chemistry, vol. 44, p. 1654-1657 Feb. 27, 2001.

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