Process for the preparation of 2-substituted 5-nitroso-4,6-diami

Details Process for the preparation of 2-substituted 5-nitroso-4,6-diami Process for the preparation of 2-substituted 5-nitroso-4,6-diami

1988-09-13

1989-05-16

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544317, 544326, C07D23930

Patent

active

048311391

ABSTRACT:
Process for the preparation of 2-substituted 5-nitroso-4,6-diaminopyrimidines. Malonic dinitrile and amidine are nitrosated in the presence of a nitrite salt, to form the corresponding amidine salt of isonitrosomalononitrile. The latter is converted to the end product in the presence of an aprotic polar solvent by heat treatment in a basic medium.

REFERENCES:
patent: 4145548 (1979-03-01), Rose
Barton and Ollis, Comprehensive Org. Chem. pp. 41-42, (1979).
Roberts and Caserio, Basic Principles of Organic Chemistry.
W. Traube, Ber., 37, 4544 (1904).
H. Sato et al., Chemical Abstracts, 47, 5946 (1953).
M. F. Mallette u.a., J. Am. Chem. Soc., 69, 1814 (1947).
E. C. Taylor u.a., J. Am. Chem. Soc., 81, 2442 (1959).

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