Process for the preparation of 2-substituted 5-alkyl-pyridines

Details Process for the preparation of 2-substituted 5-alkyl-pyridines Process for the preparation of 2-substituted 5-alkyl-pyridines

1993-10-07

1995-05-30

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546252, C07D21361

Patent

active

054202841

ABSTRACT:
The title compounds of the formula ##STR1## can be prepared by cyclization of aminomethylenated 2-pentenoic acid derivatives of the formula ##STR2## where R, X, R.sup.1, R.sup.2 and Z have the meaning given in the description,
in the presence of acids or ammonia. Preferably, aminomethylenated pentenoic acid derivatives are employed which can be prepared from pentenoic acid derivatives of the formula

REFERENCES:
patent: 3632807 (1972-01-01), Maurer et al.
patent: 4348396 (1982-09-01), Kierstead et al.
patent: 4386209 (1983-05-01), McGill et al.
patent: 4404388 (1983-09-01), Fah et al.
patent: 4405552 (1983-09-01), Miesel
patent: 4473696 (1984-09-01), Hartmann et al.
patent: 4479001 (1984-10-01), Johnston et al.
patent: 4491468 (1985-01-01), Johnston et al.
patent: 4523017 (1985-06-01), Johnston et al.
patent: 4551170 (1985-11-01), Johnston et al.
patent: 4628099 (1986-12-01), Johnston et al.
patent: 4658031 (1987-04-01), Hartmann et al.
patent: 4687854 (1987-08-01), Hartmann et al.
patent: 4738924 (1988-04-01), Kulla et al.
patent: 4753673 (1988-06-01), Johnston et al.
patent: 4849432 (1989-07-01), Shiokawa et al.
patent: 4897488 (1990-01-01), Gallenkamp et al.
patent: 5010201 (1991-04-01), Kaufmann et al.
patent: 5053516 (1991-10-01), Hartmann et al.
Advanced Organic Chemistry, "Reactions, Mechanisms, and Structure", Jerry March, pp. 20-22, 1985.
Chemical Abstract: 27-Heterocycles, vol. 97, 1982, p. 805; 182171q: "Novel ring opening of aminoheterocycles: . . . ", A. R. Katritzky, et al.
J. J. Baldwin et al., "Utilization of . . . Acid Derivatives", J. Org. Chem 43, pp. 2529-2535 (1978).
Abstract of JP 55/76 863, Pharmaceuticals, p. 4, Week C30, 1980.
J. Shabtai et al., "Base-Catalyzed . . . Acrylates", J. Org. Chem 46, pp. 3795-3802 (1981).
M. Prochazka et al., "Isomerization of Unsaturated Nitriles", Coll. Czech. Chem. Comm., vol. 35, pp. 1224-1234 (1970).
W. S. Johnson et al., "Stereochemistry of . . . the Litsenolides", J. Org. Chem., vol. 47, pp. 163-167 (1982).

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