Process for the preparation of 2-phenyl ethanol

Details Process for the preparation of 2-phenyl ethanol Process for the preparation of 2-phenyl ethanol

1999-02-24

2000-12-26

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 2700

Patent

active

061662690

ABSTRACT:
The present invention provides an improved process for the preparation of 2-phenyl ethanol [CAS 60-12-8] by catalytic hydrogenation of styrene oxide [CAS 96-09-3] with supported platinum group metal catalysts in the presence of an organic as well as inorganic base as a promoter, using alcohol as a solvent. The reaction is carried out at a temperature ranging between 40-120.degree. C. and the hydrogen pressure of 50-800 psig, under stirring conditions. After the reaction is complete, the reaction mixture is cooled to room temperature, catalyst is separated from the product by conventional methods like filtration. This invention is particularly useful as an alternative to the conventional methods like Grignard synthesis and Friedel-Craft alkylation for manufacture of 2-phenyl ethanol. This invention eliminates the handling of dangerous diethyl ether solvent, ethylene oxide and the use of AlCl.sub.3 which poses serious effluent problems. The proposed invention produces 2-phenyl ethanol selectively with highest purity via the catalytic hydrogenation of styrene oxide.

REFERENCES:
patent: 1787205 (1930-12-01), Loehr
patent: 2524096 (1950-10-01), Wood
patent: 2822403 (1958-02-01), Hopff
patent: 3579593 (1971-05-01), Wood
patent: 4064186 (1977-12-01), Gibson
patent: 4943667 (1990-07-01), Hoeldrich
Roberts, "Basic Principles of Organic Chemistry," p. 664, 1964.

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