Process for the preparation of 2-methylthiazole-5-carboxylates

Details Process for the preparation of 2-methylthiazole-5-carboxylates Process for the preparation of 2-methylthiazole-5-carboxylates

1992-08-11

1999-03-09

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27704

Patent

active

058802886

ABSTRACT:
An improved process for the preparation of alkyl 4-halomethyl -2-methylthiazole-5-carboxylate comprising contacting a solution of alkyl 4-(halo)-2-chloroacetoacetate in acetonitrile with thioacetamide in the presence of an amine, such as triethylamine.

REFERENCES:
patent: 3794636 (1974-02-01), Girgis
patent: 5045554 (1991-09-01), Alt et al.
Liebscher et al. "Ring Transformation via Bridged 1,3-Dicarbonyl Heteroanalogs Part II." Synthesis, Dec. 1989, pp. 968-970.

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