Process for the preparation of 2-[(diphenylmethyl) thio]...

Details Process for the preparation of 2-[(diphenylmethyl) thio]... Process for the preparation of 2-[(diphenylmethyl) thio]...

2007-03-06

2007-03-06

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

Reexamination Certificate

active

10543748

ABSTRACT:
Process for the preparation of 2-[(diphenylmethyl)thioacetamide, an intermediate for the preparation of Modafinil which is a CNS stimulant and used for the treatment of narcolepsia. The process comprises reacting 2-[(diphenylmethyl)thio]acetic acid with alcohols, in presence of catalytic amount of inorganic acid or organic acid at reflux temperature of alcohol to obtain corresponding ester which is reacted with ammonia to give 2-[(diphenylmethyl)thio]acetamide. If desired 2-[(diphenylmethyl)thioacetamide thus produced is reacted with hydrogen peroxide to produce Modafinil.

REFERENCES:
patent: 4177290 (1979-12-01), Lafon
patent: 4927855 (1990-05-01), Lafon
patent: 6649796 (2003-11-01), Naddaka et al.
patent: 0 233 106 (1987-08-01), None
patent: 1 520 812 (1975-10-01), None

Affiliated with

Also associated with

Rating

Process for the preparation of 2-[(diphenylmethyl) thio]... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 2-[(diphenylmethyl) thio]..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 2-[(diphenylmethyl) thio]... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3772772