Process for the preparation of 2-cyanoethylphosphinic esters

Details Process for the preparation of 2-cyanoethylphosphinic esters Process for the preparation of 2-cyanoethylphosphinic esters

1997-08-26

1999-11-23

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558134, 558145, 558167, C07F 932

Patent

active

059903376

ABSTRACT:
The invention relates to a process for the preparation of phosphorus-containing compounds of the formula (I) ##STR1## where R.sup.1 and R.sup.2 are identical or different and are a straight-chain or branched alkyl radical having 1 to 8 carbon atoms, a cyclohexyl-, cyclopentyl-, aryl-, halogen-, (C.sub.1 -C.sub.6)-alkyl- or (C.sub.1 -C.sub.6)-alkoxy-substituted aryl radical, where R.sup.1 and R.sup.2, together with the phosphorus atom and the oxygen atom, can also form a ring, in particular an oxaphosphorin ring, which comprises metering acrylonitrile at elevated temperature into a compound of the formula (II) ##STR2## where R.sup.1 and R.sup.2 are as defined above.

REFERENCES:
patent: 4594199 (1986-06-01), Thottathil
patent: 5051524 (1991-09-01), Baylis
patent: 5407922 (1995-04-01), Marescaux et al.
CA:117:17188, abs of JP04029237, Jan. 1992.
CA:122:160936 abs of EP632050, Jan. 1995.
Wolfgang Froestl: "Phosphinic acid analogues of GABA" Journal of Medicinal Chemistry, Bd. 38, Nr. 17, 1995, Washington D.C., pp. 3297-3312, XP002043375.

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