Process for the preparation of 2-chloro-5-alkylaminomethyl-pyrid

Details Process for the preparation of 2-chloro-5-alkylaminomethyl-pyrid Process for the preparation of 2-chloro-5-alkylaminomethyl-pyrid

1993-02-09

1995-01-17

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546334, 546336, C07D21326, C07D21340, C07D21336, C07D21356

Patent

active

053826710

ABSTRACT:
The invention relates to a new process for the preparation of 2-chloro-5-alkylaminomethyl-pyridines of the formula (I) ##STR1## in which R represents alkyl. In this process, 2-chloro-5-aminomethyl-pyridine is reacted with formic acid at temperatures between 20.degree. C. and 200.degree. C., if appropriate in the presence of a diluent, the 2-chloro-5-formylaminomethyl-pyridine which has been formed in this process is reacted without intermediate isolation (in situ) with alkylating agents at temperatures between 0.degree. C. and 100.degree. C., if appropriate in the presence of an acid acceptor, if appropriate in the presence of a diluent, and, finally, the 2-chloro-5-(N-alkyl-N-formyl-aminomethyl)-pyridines thus formed of the general formula (V) ##STR2## in which R has the abovementioned meaning,
are reacted with aqueous alkali metal hydroxide solution at temperatures between 20.degree. C. and reflux temperature, if appropriate after volatile components have been distilled off.
The compounds (I) are, for example, intermediates for the preparation of insecticidally active substances.

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