Process for the preparation of 2-carboxypyrazine 4-oxides

Details Process for the preparation of 2-carboxypyrazine 4-oxides Process for the preparation of 2-carboxypyrazine 4-oxides

1988-02-05

1989-09-12

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D24118

Patent

active

048661783

ABSTRACT:
A process for the preparation of 2-carboxpyrazine 4-oxides having the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, represent a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms, by oxidation of the corresponding 2-carboxypyrazines. The 2-carboxypyrazines are reacted under stirring with an aqueous solution of H.sub.2 O.sub.2, at a pH ranging between 0.5 and 5, in the presence of a catalyst selected from the group consisting of tungstic acid, a isopolytungstic acid, a heteropolytungstic acid, molybdic acid, an isopolymolybidic acid, a heteropolymolybdic acid, and an alkali metal salt thereof.

REFERENCES:
patent: 3702831 (1972-11-01), Chiavellier et al.
patent: 4002750 (1977-01-01), Ambrogi et al.
Kobayashi et al., Chem. Pharm. Bull. 22(9), 2097-2100, (1974).
Nagy, et al., Chem. Abstracts, vol. 100 (1984), entry 51464v.

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