Process for the preparation of 2-bromo-.alpha.-ergocryptine

Details Process for the preparation of 2-bromo-.alpha.-ergocryptine Process for the preparation of 2-bromo-.alpha.-ergocryptine

1986-05-30

1987-09-29

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

260694, 546 67, 546 68, 546 69, C07D51902

Patent

active

046970177

ABSTRACT:
The invention relates to a novel process for the preparation of 2-bromo-.alpha.-ergocryptine and its acid addition salt by brominating .alpha.-ergocryptine in such a way that the bromination is carried out at room temperature by using a dimethylsulphoxide-hydrogen bromide mixture containing no more 0.02% of water and, if desired, converting the thus-obtained 2-bromo-.alpha.-ergocryptine to an acid addition salt in a known manner.

REFERENCES:
patent: 3752814 (1973-08-01), Fluckiger et al.
patent: 3752888 (1973-08-01), Fluckiger et al.
patent: 4348391 (1982-09-01), Stutz et al.
patent: 4542135 (1985-09-01), Kobel et al.
patent: 4609731 (1986-09-01), Jurgec et al.
Troxler et al, Helv. Chim. Acta. vol. 40, 2160 (1957).

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