Process for the preparation of 2-bromo-8-ergolinyl compounds

Details Process for the preparation of 2-bromo-8-ergolinyl compounds Process for the preparation of 2-bromo-8-ergolinyl compounds

1984-11-05

1990-11-13

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546 68, 546 69, C07D45704, C07D45706, C07D49812

Patent

active

049703145

ABSTRACT:
2-bromo-8-ergolinyl compounds of the formula ##STR1## wherein R.sup.8 is NH.sub.2, NH--CONEt.sub.2, CONH.sub.2, ##STR2## and ##STR3## wherein R.sup.1 =C.sub.1-4 -alkyl and

REFERENCES:
patent: 4219555 (1980-08-01), Rucman et al.
patent: 4352909 (1982-10-01), Barda et al.
patent: 4356305 (1982-10-01), Szantag et al.
patent: 4609731 (1986-09-01), Jurgec et al.
Radhakrishnamurti et al., Tetrahedron Letters, No. 54, pp. 4765-4767 (1969).
Berde et al, Ergot Alkaloids and Related Compounds, pp. 40-41 (1978).
Hart et al., "The Reaction of Bromine with Cyclohexene in Carbon Tetrachloride . . . , " J. Chem. Soc. Perkin trans II (1983), pp. 1087-1092.
Radhakrishnamurti et al. ". . . Catalytic Effect of Acetic Acid on Reactions-with Hydrogen Halide," Chem. Abst. 72:54437c.
Troxter et al., "Substitutionen am Ringsystem der Lysergsaure . . . ," Helv. Acta. XL (1957), pp. 2160-2170.

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