Process for the preparation of 2-amino-s-triazines

Details Process for the preparation of 2-amino-s-triazines Process for the preparation of 2-amino-s-triazines

1985-03-25

1986-05-06

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544205, C07D25116, C07D25118, C07D25142

Patent

active

045873372

ABSTRACT:
The present invention relates to a process for the preparation of 2-amino-s-triazines in three stages. In the first stage nitriles, alcohols and hydrogen chloride are reacted to form the corresponding imido-ester hydrochlorides. In the second stage, the imido-ester hydrochlorides are reacted with cyanamide in the aqueous phase to form the N-cyanimido-esters, which comprises carrying out the first stage in the presence of acetic acid esters and the second stage in an aqueous solution which has been brought to a pH value of 5-8 by addition of bases, and reacting the N-cyanimido-esters with O-alkylisourea, S-alkylisothiourea, guanidine or amidine salts in the presence of a base in the third stage. The 2-amino-s-triazines can be prepared in a high purity and with good yields in this manner.

REFERENCES:
patent: 3154547 (1964-10-01), Huffman
Huffman et al., J. Org. Chem., pp. 1816-1821, (1963).
Lwowski, Synthesis, p. 263 (1971).
Pinner, "Die Imidoether and the Derivate" pp. 26-27, Berlin (1892).

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