Process for the preparation of 2-amino-5-methyl-pyridine

Details Process for the preparation of 2-amino-5-methyl-pyridine Process for the preparation of 2-amino-5-methyl-pyridine

1993-04-06

1994-07-26

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546347, C07D21373, C07D21318, C07D21320

Patent

active

053328248

ABSTRACT:
The invention relates to a novel process and novel intermediates for the preparation of 2-amino-5-methylpyridine (I) ##STR1## The process is characterized in that in a first step 3-methyl-pyridine 1-oxide of the formula (II) ##STR2## is reacted with a trialkylamine of the general formula (III)

REFERENCES:
patent: 4386209 (1983-05-01), McGill et al.
patent: 4405790 (1983-09-01), McGill et al.
R. A. Abramovitch et al., "Direct Acylamination of Pyridine 1-Oxides", The Journal of Organic Chemistry, vol. 39, No. 13, Jun. 28, 1974, pp. 1795-1802.
R. A. Abramovitch et al., "Direct Acylamination of 3-Substituted . . . the Substituent", J. Org. Chem., vol. 39, No. 13, pp. 1802-1807, (1974).
K. Wachi et al., "Studies on 1,3-Benzoxazines . . . N-Oxides", Chem. Pharm. Bull., 28(2), pp. 465-472 (1980).
Abstract of EP 62,264, 27-Heterocycles, vol. 98, (1983), pp. 541-542.
R. A. Abramovitch, et al., "Regiospecific Animation . . . Polystyrene", Heterocycles, vol. 26, No. 8, (1987), pp. 2065-2068.
V. Boekelheide et al., "Rearrangements of N-Oxides. A Novel . . . Aldehydes", J. Am. Chem. Soc., vol. 76, Mar. 5, 1954, pp. 1286-1291.

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