Process for the preparation of 2-amino-4,5,3',4'-tetramethoxyben

Details Process for the preparation of 2-amino-4,5,3',4'-tetramethoxyben Process for the preparation of 2-amino-4,5,3',4'-tetramethoxyben

1999-03-12

2000-01-04

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564329, 564321, 564416, 568306, 568314, 568332, 568333, C07C21784, C07C21790

Patent

active

06011178&

ABSTRACT:
2-Amino-4,5,3',4'-tetramethoxybenzophenone of the formula: ##STR1## is prepared by mononitration of 3,3',4,4'-tetramethyoxybenzophenone using nitric acid in the presence of acetic acid, and subsequent reduction of the nitro group. The compound is an intermediate in the synthesis of active ingredients against rheumatoid arthritis.

REFERENCES:
patent: 5650410 (1997-07-01), Sohda et al.
Lawson et al, J.Chem.Soc., vol. 125, p. 626, 1924.
Harrison et al, Compendium of Organic Synthetic Methods, p. 266, 1971.
March, Advanced Organic Chemistry, third edition, p. 486, 1985.
Munchhof et al., Journal Of Organic Chemistry, vol. 60, No 23, (Nov. 3, 1995), pp. 7086 and 7087, (Munchhof et al.).
Upton et al., Journal Of Pharmacy and Pharmacology, vol. 50, No. 5, May, 1998, pp. 476 yo 482, (Upton et al.).

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