Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1990-06-15
1993-04-27
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2722, C07H 1919
Patent
active
052063518
ABSTRACT:
A process for the preparation of 2-amino-9-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl) adenine (V) is described. The process uses a protected 2,6-di(tri-alkylsilylamino)-9-trialkylsilylpurine (II) which is reacted with protected chlorosugar 2,3,5-tri-O-benzyl-1-chloro-D-arabinofuranose (III) and then the protection groups are removed from the 2 and 6 positions. The process provides a 9-beta-D-arabinofuranosyl-2-fluoroadenine (VII) which is an antileukenine drug.
REFERENCES:
patent: 4210745 (1980-07-01), Montgomery
patent: 4287188 (1981-09-01), Schaeffer
Anderegg et al. Anal. Chem. 56:1351-1355 (1984).
LaMontagne Maurice P.
Markovac Anica
Ash Stevens, Inc.
Brown Johnnie R.
Kunz Gary L.
McLeod Ian C.
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