Process for the preparation of 2-alkylpyrimidines

Details Process for the preparation of 2-alkylpyrimidines Process for the preparation of 2-alkylpyrimidines

1988-05-16

1991-03-12

Rivers, Diana

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

564159, C07D23926

Patent

active

049994271

ABSTRACT:
2-Alkylpyrimidines are prepared from 1,3-diaminopropane and an appropriate alkanecarboxylic acid in a continuous vapor phase process without isolating any of the reaction intermediates. Improvements in each reaction step, namely, the amidation, the cyclization/dehydration and the dehydrogenation, contribute to the overall success of the continuous vapor phase process.

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Aspinall, J. Am. Chem. Soc., vol. 62, pp. 2160-2162 (08/40).
Tsuchiya, et al., Yakugaku Zasshi, vol. 96(8), pp. 1005-1012 (1976), English translation supplied.
Tsuchiya, et al., Yakugaku Zasshi, vol. 97(4), pp. 373-381 (1977), English translation supplied.

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