Process for the preparation of 2-acylamino-6-halopurine from 2,9

Details Process for the preparation of 2-acylamino-6-halopurine from 2,9 Process for the preparation of 2-acylamino-6-halopurine from 2,9

1990-10-26

1995-07-18

Gupta, Yogendra N.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

544277, C07D47340

Patent

active

054342635

ABSTRACT:
2-Acylamino-6-halopurine can be prepared by halogenation of 2,9-diacylguanine (2-acylamino-6-oxo-9-acylpurine) with phosphorus oxychloride or phosphorus oxybromide in the presence of a base and of a salt with subsequent hydrolysis of the reaction product.

REFERENCES:
patent: 4405781 (1983-09-01), Bader et al.
patent: 4736029 (1988-04-01), Harnden et al.
Bendich et al, J. Am. Chem. Soc. vol. 76, 6073-6077, 1954.
W. A. Bowles et al., J. Med. Chem. 6, 1963, pp. 471-480.
H. Hrebabecky et al., Nucleic Acid Chemistry, 1978, pp. 13-14.

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