Process for the preparation of 2-(4-hydroxyphenyl)-3-methylbutyr

Details Process for the preparation of 2-(4-hydroxyphenyl)-3-methylbutyr Process for the preparation of 2-(4-hydroxyphenyl)-3-methylbutyr

1983-06-06

1985-08-27

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 75, C07C 6501

Patent

active

045379882

ABSTRACT:
An integrated process for the preparation of 2-(4-hydroxyphenyl)-3-methylbutyric acid from the corresponding 2-(4-chlorophenyl)-3-methylbutyronitrile through hydrolysis of the nitrile by strong base to the corresponding carboxylic acid followed by formation of the corresponding phenol by nucleophilic displacement of the chlorine with a strong base in the presence of copper salts, and if so desired metallic copper, is described.

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