Process for the preparation of 2,4-dichloro-3,5-dimethyl-fluorob

Details Process for the preparation of 2,4-dichloro-3,5-dimethyl-fluorob Process for the preparation of 2,4-dichloro-3,5-dimethyl-fluorob

1999-03-04

2000-11-21

Siegel, Alan

Organic compounds -- part of the class 532-570 series

Organic compounds

Halogen containing

570143, C07C 1908, C07C 2200

Patent

active

061505714

ABSTRACT:
A method for preparing 2,4-Dichloro-3,5-dimethylfluorobenzene, wherein the 2,4-Dichloro-3,5-dimethylfluorobenzene can be prepared in highisomeric selectivities when 3,5-dimethylfluorobenzene is chlorinated in the presence of Friedel-Crafts catalysts and a sulfur-containing co-catalyst.
The invention is also directed to an intermediary for preparing a pharmaceutically-active compound including 4-dichloro-3,5-dimethyl fluorobenzene.

REFERENCES:
patent: 4925994 (1990-05-01), Mais et al.
patent: 5475164 (1995-12-01), Bussmann
patent: 5684217 (1997-11-01), Mais et al.

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