Process for the preparation of 2,4-diamino-5-benzylpyrimidines

Details Process for the preparation of 2,4-diamino-5-benzylpyrimidines Process for the preparation of 2,4-diamino-5-benzylpyrimidines

1987-07-31

1988-12-06

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544349, 558410, 558408, 558388, 549434, 549437, 549439, 549442, 549445, C07D23928

Patent

active

047897430

ABSTRACT:
The invention relates to a process for the preparaton of compounds of the formula I by reacting an alkali metal alcoholate with a compound of the formula II in the presence of an aliphatic ester such as methyl formate, and then condensing guanidine with the resulting compound of the formula III.
The compound of the formula II can be prepared by reacting the corresponding benzaldehyde with acrylonitrile in the presence of diazabicyclo-2,2,2,-octane. ##STR1##

REFERENCES:
patent: 3671564 (1972-06-01), Cresswell et al.
patent: 3743669 (1973-07-01), Hillman et al.

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