Process for the preparation of 2,2-diphenyl-4-(dimethylamino)-pe

Details Process for the preparation of 2,2-diphenyl-4-(dimethylamino)-pe Process for the preparation of 2,2-diphenyl-4-(dimethylamino)-pe

1979-06-18

1980-12-30

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

564319, C07C 9710, C07C12178

Patent

active

042422744

ABSTRACT:
A process for the preparation of 2,2-diphenyl-4-(dimethylamino)-pentane nitrile. A charge mixture is prepared comprising diphenylacetonitrile, 1-(dimethylamino)-2-halopropane, a base, water, a water-immiscible organic solvent, and a quaternary salt selected from a group consisting of tetrabutylammonium halides, tetrabutylammonium hydrogen sulfate, cetyltrimethylammonium halides, benzyltriphenylphosphonium halides, and methyltrialkyl (C.sub.8 -C.sub.10) ammonium halides. The mixture is heated under an inert atmosphere to effect formation of 2,2-diphenyl-4-(dimethylamino)-pentane nitrile by reaction of diphenylacetonitrile, 1-(dimethylamino)-2-halopropane and a base.

REFERENCES:
patent: 3992432 (1976-11-01), Napier et al.
patent: 4056509 (1977-11-01), Verbrugge et al.
Schultz et al., J. Amer. Chem. Soc., vol. 69, 188 and 2458 (1947).
Brandstrom et al., Tetrahedron Letters, No. 6, pp. 473-474 (1972).

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