Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1991-05-10
1992-10-13
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
560263, 560264, C07C 5948
Patent
active
051552604
ABSTRACT:
The invention relates to an improved process for the preparation of 2,2-dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid of Formula (I) ##STR1## which comprises reacting an ester of the general Formula (X) ##STR2## wherein X represents halogen and Z stands for a straight or branched chain C.sub.1-8 alkylene group optionally substituted by one or two 2,2-dimethyl-5-halopentanoyloxy group(s), wherein halo represents chlorine or bromine, and in which alkylene group one or two methylene group(s) may be optionally replaced either by hetero atom(s) or by a bivalent heterocyclic group--with an alkali salt of 2,5-dimethylphenol of Formula (II) ##STR3## or with an ester of the latter formed with a lower alkanoic acid, and hydrolizing the aryloxy-substituted ester of the general Formula (XI) thus obtained. Furthermore the invention relates to intermediate compounds of the general Formula (X), wherein X and Z are as stated above, and to a process for the preparation thereof.
REFERENCES:
patent: 3674836 (1972-07-01), Greger
patent: 3759986 (1973-09-01), Greger
patent: 3847994 (1974-11-01), Gregor et al.
patent: 4665226 (1987-05-01), Vearney
Feher Gabor
Kovacs Gabor
Kovacs nee Bozo Eva
Krasznai Gyorgy
Moravcsik Imre
Egis Gyogyszergyar
Killos Paul J.
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