Process for the preparation of 17-phenyl-18,19,20-thinor-pgf...

Details Process for the preparation of 17-phenyl-18,19,20-thinor-pgf... Process for the preparation of 17-phenyl-18,19,20-thinor-pgf...

2007-01-02

2007-01-02

Carr, Deborah D. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

C554S141000, C554S159000, C554S222000, C549S312000, C549S465000, C549S466000

Reexamination Certificate

active

10478849

ABSTRACT:
The present invention provides a new and effective process for the synthesis of 17-phenyl-18,19,20-trinor-PGF2αand its derivatives, including the anti-glaucoma drugs Bimatoprost and Latanoprost. The benefit of the present invention rises inter alia from the fact that a major intermediate involved in the synthesis of the above compounds may be isolated from a mixture containing also an undesired isomer, by crystallization. In addition, the undesired isomer may be oxidized to give the starting compound, which is then recycled.

REFERENCES:
patent: 3931279 (1976-01-01), Nelson
patent: 4346228 (1982-08-01), Skuballa et al.
patent: 5352708 (1994-10-01), Woodward et al.
patent: 5688819 (1997-11-01), Woodward et al.
patent: 5698733 (1997-12-01), Hellberg et al.
patent: 6689901 (2004-02-01), Henegar
patent: 0850926 (1998-07-01), None
patent: 0930296 (1999-07-01), None
patent: WO 93/00329 (1993-07-01), None
patent: WO 95/28729 (1995-12-01), None
patent: WO 01/55101 (2001-08-01), None
patent: WO 01/87816 (2001-11-01), None
Bahram Resul, et al (1993) “Phenyl-Substituted Prostaglandins: Potent and Selective Antigalucoma Agents.” J Med Chem, 36, 243-248.
Chem Abstr, CAN 117:111373, AN 1992 511373.
DeLong, et al, (1993) Bioorg. Med. Chem Lett, 2000, v 10, 1519.
Disselnkoetter, et al, (1982) Liebigs Ann Chem, 150.
Dolence, et al, (1987) Tetrahedron Lett v.28, 43.
Exp Eye Res., 2004, v.78, 767.
J Ocular Pharmacol, Therap, 2003, v. 19, 501.
Magerlein B J et al “Synthesis of 17-Phenyl-18, 19,20-Trinorprostaglandins” Prosraglandins Jan. 1975 vol. 9 No. 1.

Affiliated with

Also associated with

Rating

Process for the preparation of 17-phenyl-18,19,20-thinor-pgf... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 17-phenyl-18,19,20-thinor-pgf..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 17-phenyl-18,19,20-thinor-pgf... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3822653