Process for the preparation of 17(20)ene-21-steroid aldehydes

Details Process for the preparation of 17(20)ene-21-steroid aldehydes Process for the preparation of 17(20)ene-21-steroid aldehydes

1976-04-22

1977-11-22

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26023955C, 2603975, C07J 3300, C07J 2100

Patent

active

040595757

ABSTRACT:
There is disclosed a process for the efficient conversion of 17-.alpha.-ethynyl 17-.beta.- hydroxy steroids into the corresponding 17(20) .alpha..beta.-unsaturated 21-steroid aldehydes. The process comprises the sequential steps of reacting the ethynyl alcohol with a diloweralkylformamide dilower-alkylacetal, suitably dimethylformamide diethylacetal, to form the corresponding 16,20 diene-21-diloweralkylamine which is then hydrolyzed to form the corresponding 17(20)-ene-21-steroid aldehyde.

REFERENCES:
patent: 3094524 (1963-06-01), Bertin et al.
patent: 3912656 (1975-10-01), Andrews et al.

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