Process for the preparation of 16,17 acetals of pregnane derivat

Details Process for the preparation of 16,17 acetals of pregnane derivat Process for the preparation of 16,17 acetals of pregnane derivat

1985-05-30

1987-09-22

Schenkman, Leonard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540 68, 540 69, 540 70, C07J 7100

Patent

active

046956255

ABSTRACT:
A process for the preparation of 16,17 acetals of pregnane derivatives by trans-ketalization of 16,17-acetonides is described.
In the instance of the preparation of 16.alpha.,17.alpha.-butylidenedioxy-11.beta.,21-dihydroxypregna-1,4-diene- 3,20-dione, a compound having useful therapeutic properties, known also as budesonide, it is possible to obtain the more active epimer with high selectivity and remarkable economic advantages in comparison with the known methods.
New 16,17 acetals of pregnane derivatives, which can be prepared by the method of the invention, are also described.

REFERENCES:
patent: 3983233 (1976-09-01), Brattsand et al.
patent: 4404200 (1983-09-01), Thalen et al.

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