Process for the preparation of 14-hydroxymorphinan derivatives

Details Process for the preparation of 14-hydroxymorphinan derivatives Process for the preparation of 14-hydroxymorphinan derivatives

1975-11-18

1977-04-12

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603405, 260465R, C07D22128

Patent

active

040174972

ABSTRACT:
N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound 3,14-dihydroxy-N-cyclobutylmethylmorphinan has been found to possess potent agonist/antagonist activity. A new and novel total synthesis for the preparation of these compounds is described herein.

REFERENCES:
patent: 3166559 (1965-01-01), Sawa et al.
patent: 3775414 (1973-11-01), Monkovic et al.
patent: 3819635 (1974-06-01), Pachter et al.
Okabe, J. Pharm. Soc., Japan (Yakugaku Zasshi), v.82, 1512-1514 (1962).
Lester et al., Chemical Abstracts, vol. 62, pp. 16311f-16313h, (1965).
Barltrop et al., J. Chem. Soc. 1038-1041 (1952).
Chemical Abstracts, vol. 47, 1165h (1953).
Sawa et al., Tetrahedron, v.24, 261-266 (1968).
Sawa et al., Tetrahedron, v.24, pp. 6185-6196 (1968).
Pettit et al., Desulfurization with Raney Nickel, Chap. 5, "Organic Reactions," v.12, N.Y. (1962), pp. 378-385.

Affiliated with

Also associated with

Rating

Process for the preparation of 14-hydroxymorphinan derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 14-hydroxymorphinan derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 14-hydroxymorphinan derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1281040