Process for the preparation of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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08080663

ABSTRACT:
An industrially acceptable process for the preparation of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine. The cis-isomer of 2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine is known generally as Cevimeline.

REFERENCES:
patent: 4855290 (1989-08-01), Fisher
patent: 4861886 (1989-08-01), Haga
patent: 5571918 (1996-11-01), Hayashi
http://medical-dictionary.thefreedictionary.com/aryl (2010).
Sigma-Aldrich Chemical Catalog, on-line structure search (2010).
Bos M., EPC-Synthesis of (S)-3-Hydroxy-3-Mercaptomethyl-Quinuclidine, A Chiral Building Block for the Synthesis of the Muscarinic . . . , Heterocycles; 1994;38(8):1889-1896.
Sorbera L.A., Cevimeline Hydrochloride; Drugs of the Future; 2000;25 (6):558-562.

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