Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-12-11
2010-11-23
Dentz, Bernard (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C549S318000, C435S126000
Reexamination Certificate
active
07838693
ABSTRACT:
The present invention provides novel methods for preparing a key intermediate, 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-γ-lactone (2), for the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl)cytosine (1), which is a potent and selective anti-hepatitis C virus agent.
REFERENCES:
patent: 2005/0009737 (2005-01-01), Clark
patent: 2005/0025916 (2005-02-01), Nakanishi
patent: WO2006/012440 (2006-02-01), None
H. Ansel et al., Pharmaceutical Dosage Forms & Drug Delivery system (6thEd. 1995) pp. 196-197.
Cedilote Miall
Cleary Thomas
Iding Hans
Zhang Ping-sheng
Dentz Bernard
Hoffmann-La Roche Inc.
Johnston George W.
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
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