Process for the preparation of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

Reexamination Certificate

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Reexamination Certificate

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07619082

ABSTRACT:
The invention relates to a process for the preparation of a compound of the formula (I) by reacting a compound of the formula (II) with a compound of the formula (III) characterized by dissolving the compounds of the formula (II) and formula (III) in a water-inmiscible organic solvent in the presence of a phase transfer catalyst, reacting with a.) an aqeuos solution of a base, or b.) a base in solid form directly and if desired transforming the compound of formula (I) thus obtained into its salt.

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patent: 6600039 (2003-07-01), Heja et al.
patent: WO 97/15556 (1997-05-01), None
patent: WO 01/05791 (2001-01-01), None
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IIIi, Synthesis, No. 2, p. 136 (1979).
Jones, K., et al., Chiral Induction in Aryl Radical Cyclisations, Tetrahedron Letters, vol. 30, No. 20, 2657-2660, 1989.
Sleboka-Tilt, et al., O Exchange Accompanying the Basic Hydrolysis of Primary, Secondary, and Tertiary Toluamides. 2. The Importance of Amine Leaving Abilities from the Anionic Tetrahedral Intermediates, J. Am. Chem. Soc., vol. 112, No. 23; 1990; 8507-8514.
Ohgawara, Phase Transfer Catalyst, Ghoseishiyaku, Khodansha (1980), pp. 188-189 (with English translation).
Rao et al., Synthesis and Reactions of 2-Bis(methylthio)methylene-1-methy1-3-oxoindole: A Facile Access to Benzo- and Heterocyclo-Fused Carbazoles and Indoles, Tetrahedron 55 (1999), pp. 11563-11578.
Phase Transfer Catalyst, Shokubaikouza, Khodansha (1986), Chapter 8, vol. 10. pp. 164-165 (with English translation).

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