Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-03-22
2008-08-19
Stockton, Laura L. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07414137
ABSTRACT:
The present invention is directed to practical high-yielding synthetic processes for preparing 3,4-disubstituted-thiazolidin-2-ones, which do not compromise the absolute stereochemical integrity of the compounds. The present invention is also directed to novel compounds of 3,4-disubstituted-thiazolidin-2-ones. The compounds prepared by the present invention are useful in the synthesis and manufacture of compounds (such as latrunculins and/or their analogs) for treating diseases or conditions associated with inhibiting actin polymerization.
REFERENCES:
patent: 5798380 (1998-08-01), Kaufman et al.
patent: 5925658 (1999-07-01), Ishihara et al.
patent: 6110912 (2000-08-01), Kaufman et al.
patent: 6586425 (2003-07-01), Kaufman et al.
patent: 7320974 (2008-01-01), Lampe et al.
patent: 2006/0217427 (2006-09-01), Lampe et al.
patent: WO 06/10897 (2006-10-01), None
International Search Report for PCT/US07/64786, mailed May 2, 2008.
M.E.F. Braibante, et al., “The Use of Curtius Rearrangement in the Synthesis of 4-Aminothiazolidines,”Synthesis, (1999) No. 6, 943-946.
A. Fürstner et al., “Catalysis-Based Total Synthesis of Latrunculin B,”Angew. Chem. int. Ed., (2003) 42, 5358-5360 XP-002391423.
A. Fürstner, “Diverted total synthesis: Preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties,”PNAS, (2005) vol. 102, No. 23, 8103-8108.
J.D. Park, et al., “Cysteine Derivatives as Inhibitors for Carboxypeptidase A: Synthesis and Structure-Activity Relationships,”J. Med. Chem., (2002) 45, 911-918.
A.B. Smith III et al., “Total Synthesis of the Latrunculins,”J. Am. Chem. Soc., (1992) 114, 2995-3007.
J.D. White and M. Kawasaki, “Total Synthesis of (+)-Latrunculin A, an Ichthyotoxic Metabolite of the SpongeLatrunculia magnifica, and Its C-15 Epimer,”J. Org. Chem., (1992) 57, 5292-5300.
DeCamp Jonathan B.
She Jin
Watson Paul S.
Howrey LLP
Inspire Pharmaceuticals Inc.
Kung Viola T.
Stockton Laura L.
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