Process for the preparation of 11.beta.-hydroxy-18-alkyl-estrane

Details Process for the preparation of 11.beta.-hydroxy-18-alkyl-estrane Process for the preparation of 11.beta.-hydroxy-18-alkyl-estrane

1975-07-18

1977-06-21

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26023957, 26039745, 195 51S, C07J 7100, C07J 500

Patent

active

040310744

ABSTRACT:
The present invention relates to a novel process for the preparation of 11.beta.-hydroxy-18-alkyl-estrane compounds by reacting an 11.beta.-hydroxy-13-methyl-gonane compound with an excess of an acylhypoiodite to give an estrano-18,11.beta.-lactone, reacting the latter compound with a Grignard compound or an alkyl lithium compound, possibly after hydrolysis of the lactone, and reducing the thus-obtained 11.beta.-hydroxy-18-alkyl-18-ketone to the corresponding 11.beta.-hydroxy-18-alkyl-estrane compound, and to novel intermediates of the subject compounds.

REFERENCES:
patent: 3780026 (1973-12-01), Kondo et al.

Affiliated with

Also associated with

Rating

Process for the preparation of 11.beta.-hydroxy-18-alkyl-estrane does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 11.beta.-hydroxy-18-alkyl-estrane, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 11.beta.-hydroxy-18-alkyl-estrane will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-735364