Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Reexamination Certificate
2007-03-06
2007-03-06
Page, Thurman K. (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
C562S011000
Reexamination Certificate
active
10946869
ABSTRACT:
The present invention relates to a process for the preparation of 3-amino-2-hydroxypropylphosphinic acid derivatives of the formula I,which are valuable pharmaceutical active ingredients and can be used, for example, as antidepressants. The process starts from O-ethyl phosphinates of the formula II into which, after silylation with hexamethyldisilazane, the 3-amino-2-hydroxypropyl moiety is introduced by reactions with epichlorohydrin and ammonia.
REFERENCES:
patent: 5229379 (1993-07-01), Marescaux et al.
patent: 5300679 (1994-04-01), Baylis et al.
patent: 5376684 (1994-12-01), Mickel
patent: 5407922 (1995-04-01), Marescaux et al.
patent: 5424441 (1995-06-01), Mickel et al.
patent: 5500418 (1996-03-01), Mickel
patent: 5545631 (1996-08-01), Marescaux et al.
patent: 5567840 (1996-10-01), Hall et al.
Froestl et al., Phosphinic Acid Analogs of GABA. 2. Selective, Orally Active GABAB Antagonists, J. Med. Chem.; 1995; 38(17); 3313-3331.
J. G. Dingwall et al., Diethoxymethylphosphonites And Phosphinates. Intermediates For The Synthesis Of alpha, beta- And omega-aminoalkylphosphonous Acids , Tetrahedron (1989, pp. 3787-3808, vol. 45, No. 12).
J. G. Dingwall et al., Synthesis Of gamma-aminoprophylphosphonous Acids Using Hypophosphorous Acid Synthons, Phosphorus And Sulfur (1987, pp. 571-574, vol. 30).
J. G. Dingwall, New Carboxyphosphonic And Phosphinic Acid Structures Of Technical And Biological Interest, Phosphorus And Sulfur (1983, pp. 353-356, vol. 18).
Michel Belley et al., Synthesis Of The Nanomolar Photoaffinity GABA (B) Receptor Ligand CGP 71872 Reveals Diversity In The Tissue Distribution of GABA (B) Receptor Forms, Bioorganic And Medicinal Chemistry (1999, pp. 2697-2704, vol. 7).
Petr Alexander et al., Synthesis Of 9-(2-Phosphinomethoxyethyl) Adenine And Related Compounds), Collection Of Czechoslovak Chemical Communications (1994, pp. 1870-1878, vol. 59).
Wolfgang Froestl et al., Ligands For Expression Cloning And Isolation Of GABA (B) Receptors, IL Farmaco (2003, pp. 173-183, vol. 58).
Wolfgang Froestl et al., Phosphinic Acid Analogues Of GABA. 2. Selective, Orally Active GABA beta Antagonists, J. Med. Chem. (1995, pp. 3313-3331, vol. 38).
Wolfgang Froestl et al., Phosphinic Acid Analogues of GABA. 1. New Potent And Selective GABA beta Agonists, J. Med. Chem. (1995, pp. 3297-3312, vol. 38).
Huang Bao-Guo
Rudisill Duane
Subotkowski Witold
Aventis Pharmaceuticals Inc.
Gupta Balaram
Nwaonicha Chukwuma
Page Thurman K.
LandOfFree
Process for the preparation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3732099