Process for the preparation of 10-deazaaminopterin and related c

Details Process for the preparation of 10-deazaaminopterin and related c Process for the preparation of 10-deazaaminopterin and related c

1978-06-15

1979-10-23

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Plural nitrogens bonded directly to the pteridine ring system

542458, 544244, C07D47508

Patent

active

041722000

ABSTRACT:
There is disclosed an improved process for the preparation of 10-deazaaminopterin and related compounds. In accordance with this process, 6-(bromomethyl)-2,4-pteridinediamine hydrobromide is reacted with triphenylphosphine to form a phosphonium salt which is then treated with a base to yield the corresponding ylid (2,4-diamino-6-pteridinyl)methylenetriphenylphosphorane. This compound is reacted with an aromatic aldehyde such as diethyl 4-formylbenzoyl-L-glutamate to form an olefin which is then reduced catalytically to the tetrahydro derivative of the desired product. Oxidation of the tetrahydro derivative is accomplished with hydrogen peroxide.

REFERENCES:
patent: 4077957 (1978-03-01), Piper et al.

Affiliated with

Also associated with

Rating

Process for the preparation of 10-deazaaminopterin and related c does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of 10-deazaaminopterin and related c, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of 10-deazaaminopterin and related c will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-410511