Process for the preparation of 10(2-propynyl)estr-4-ene-3,17-dio

Details Process for the preparation of 10(2-propynyl)estr-4-ene-3,17-dio Process for the preparation of 10(2-propynyl)estr-4-ene-3,17-dio

1995-06-06

1996-05-14

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

552630, C07J 100

Patent

active

055169228

ABSTRACT:
This invention relates to a process for the preparation of 10-(2-propynyl)-estr-4-ene-3,17-dione, whereby this compound is synthesized utilizing ketals prepared from the addition of 2,2-dimethyl-1,3-propanediol to the starting compound, 19-norandrost-5(10)-ene-3,17-dione (NAD). A new process for the addition of the propynyl group to steroid epoxides by means of higher order cuprates is also described herein.

REFERENCES:
P. J. Bednarski et al., J. Med. Chem., 32, 203-263 1989.
Lipshutz et al. Tetrahedron letters, 28, No. 9 pp. 945-948, 1987.
P. J. Bednarski, PhD. Thesis (University of Washington), pp. 61-63, 78, 79, 96-98 (1986).
E. Erdik, Tetrahedron, 40, 641-657 (1984).
B. H. Lipshutz et al., Tetrahedron, 40, 5005-5038 (1984).
G. H. Posner, "Organic Reactions" vol. 22, pp. 253-255, 287-289 and 389-393 (1975).
Chemical Abstracts, Eleventh Collective Index, 1982-1986 Formula Index, p. 19059F.
Chemical Abstracts, 105, 115283y (1986).
B. H. Lipshutz et al, Tetrahedron Letters, 25, No. 52, 5959-5962 (1984).
B. H. Lipshutz et al., J. Org. Chem., 49, 3938-3942, (1984).
B. H. Lipshutz et al., J. Org. Chem., 49, 3928-3938, (1984).
B. H. Lipshutz et al., Tetrahedron Letters, 28, 945-948, (1987).
Bednarski, et al., J. of Med. Chem. vol. 32(1), p. 203 (1989).
P. J. Bednarski, PhD. Thesis (University of Washington), pp. 61-63, 78, 79, 96-98 (1986).
E. Erdik, Tetrahedron, 40, 641-657 (1984).
B. H. Lipshutz et al., Tetrahedron, 40, 5005-5038 (1984).
G. H. Posner, Organic Reactions, vol. 22, pp. 253-255, 287-289 and 389-393 (1974).
Chemical Abstracts, Eleventh Collective Index, 1982-1986 Formula Index, p. 19059F. 1986.
B. H. Lipshutz et al, J. Org. Chem., 49, 3938-3942 (1984).
B. H. Lipshutz et al, J. Org. Chem., 49, 3928-3938 (1984).
B. H. Lipshutz et al, Tetrahedron Letters, vol. 28, No. 9, pp. 945-948, (1987).
S. W. Smith, et al., J. of the Amer. Chem. Soc., vol. 90, No. 5, pp. 1249-1253, (1968).

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