Process for the preparation of 1-methylandrosta-1,4-diene-3,17,d

Details Process for the preparation of 1-methylandrosta-1,4-diene-3,17,d Process for the preparation of 1-methylandrosta-1,4-diene-3,17,d

1988-05-06

1989-10-03

Robinson, Douglas W.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603974, C07J 100

Patent

active

048714828

ABSTRACT:
1-Methylandrosta-1,4-diene-3,17-dione is prepared by a process wherein a 3-enol ester or 3-enol ether of general Formula II ##STR1## wherein R.sub.1 is an alkyl residue of 1-3 carbon atoms or an acyl or trialkylsilyl group of up to 10 carbon atoms in the group, is converted into the 2-bromo steroid of Formular III ##STR2## wherein the bromine substituent can be in the .alpha.- as well as in the .beta.-position, and the compound of general Formula III is converted into 1-methylandrosta-1,4-diene-3,17-dione.

REFERENCES:
patent: 3134792 (1964-05-01), Kaspar et al.
patent: 3758523 (1973-09-01), Philippson et al.
patent: 4591585 (1986-05-01), Kerb et al.
J. Am. Chem. Soc. 82, pp. 5488 to 5493 (1960).

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